Inspiration comes from the strangest places. For Ethan Nicolle it came from his little brother, his co-creator for Axe Cop. The little guy writes, Ethan illustrates.
Just casting around, looking for an inspirational spark, and boom, your 5 year old brother comes up with something that works. And a few years later a major network is turning your successful web comic into an animated web series voiced by Ron Swanson.
So that's basically awesome right there.